Why The New Corona Virus Is So Powerful, It Reveals The Whole Process Of The Life Cycle Of The Virus After Entering The Human Body

The 2020 Spring Festival has given us too much to catch off guard, and the root of all of this is related to the emerging virus, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).

Why The New Corona Virus Is So Powerful, It Reveals The Whole Process Of The Life Cycle Of The Virus After Entering The Human BodyThe 2020 Spring Festival has given us too much to catch off guard, and the root of all of this is related to the emerging virus, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).

Why a small virus has such great power, in order to understand its function, you need to start by understanding its structure, after all, the structure determines the function.

I. New Crown Structure

First, we need to know that the name of the virus is SARS-CoV-2. This new coronavirus belongs to the same coronavirus as SRAS.

Coronaviruses are named after the obvious stick-shaped particle bulges that can be observed under a microscope, which resemble the crowns of European medieval kings.

Next, look closely at the structure of the virus from the outside to the inside. There are three kinds of proteins in the outermost layer of coronavirus, which are called spike glycoprotein, small envelope glycoprotein (M protein), and membrane glycoprotein (E-protein).

Spike glycoprotein mainly recognizes and binds to host cell surface receptors and plays a key role in mediating the fusion of the viral envelope and cell membrane. In layman's terms, spike glycoprotein acts like a key, and its main function is to open the cell membrane of the host cell.

Immediately afterward, the envelope on the surface of the virus is also called the capsule, which is mainly a lipid component, which is similar to the principle of the lipid bilayer of human cell membranes and the similarity of the chemical compatibility. cell.

Finally, entering the inside of the cell, there is an RNA with a single-stranded structure. As RNA has no double-stranded structure and does not have the error-correcting ability that can match the DNA, the new crown virus is more likely to mutate.

To be clear, this RNA structure provides the structural basis for RT-PCR, the “gold standard” for the detection of new coronary pneumonia.

II. The Process of the Virus Attacking the Human Body

After completing the structural observation of our enemies, we may wish to take a closer look at a virus raid in a local battle.
First, we need to make clear that the virus cannot survive on its own, that is, it must parasitize other host cells.

When a virus parasites a cell, it usually goes through four steps: adsorption and entry, husking, biosynthesis, assembly, and exocytosis.

1. Adsorption and Infiltration:

When the virus enters the adjacent position of the alveoli through the respiratory tract, the virus specifically bind to the door locks of certain cells, such as ACE2 receptors, by using the spinous protein as a key, thereby cleverly deceiving the cells and opening the portal. The lipid envelope quickly passes through the lipid bilayer and enters the host cell.

Compared with other organs, human airway ciliary cells, and alveolar epithelial cells have higher levels of ACE2 protein, which explains why the new crown virus first chose the lungs to attack.

2. Unshelling:

After the virus enters the cell, the virus will attract the cell factory picket team-lysosome to inactivate it by its own coat-protein core capsid. This step is called "unshelling".
Because of this, the virus's genetic material, RNA, is completely exposed inside the cell. Of course, it will not just be satisfied with this.

3. Synthesis:

When the genetic material RNA has invaded the cell's synthesis workshop-ribosomes, the virus finally began its wanton reproduction. This step "synthesis" focuses on re-producing the important parts needed for the virus, so it will be mapped again To our previous description of the structure of the virus:
  • First, one-way positive-stranded RNA directs the synthesis of a number of viral-related proteins, including nucleocapsid proteins.
  • Second, one-way positive-stranded RNA is transcribed into negative-stranded RNA by using itself as a template, which in turn generates new progeny positive-stranded RNA. This process is repeated, and a large amount of new RNA is obtained.
  • Thirdly, after the negative-strand RNA is selectively converted into a fragment of the positive-strand RNA, various small proteins can be specifically synthesized.

4. Assembling and Exporting:

So far we have obtained three main parts, and we can complete the core assembly. According to some theories, lipid envelopes are mainly obtained when the exocytosis passes through the endoplasmic reticulum or the cell membrane and the lipid membrane components are obtained.

So far, the virus has completed the entire process of replication.

What will happen to its fate? Whether it is a long-term incubation or waiting for an opportunity, this involves the outcome of the virus. It can choose to passively increase as the cell replicates, or it can reproduce in large numbers, causing direct toxic killing and resource invasion to the cell.

The last question is for you. If you are a virus, what choice will you make in order to maximize the benefits of your cluster?
The content of this article is general knowledge of health knowledge, and it cannot be used as a specific diagnosis and recommendation, nor can it replace the face-to-face consultation of a licensed physician, for reference only.

The copyright of this article belongs to Tencent Medical Code. Unauthorized reprinting of this media is prohibited. Any illegal reprinting will be investigated for legal responsibility. Individuals are welcome to forward to the circle of friends.

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Corona Virus Magazine: Why The New Corona Virus Is So Powerful, It Reveals The Whole Process Of The Life Cycle Of The Virus After Entering The Human Body
Why The New Corona Virus Is So Powerful, It Reveals The Whole Process Of The Life Cycle Of The Virus After Entering The Human Body
The 2020 Spring Festival has given us too much to catch off guard, and the root of all of this is related to the emerging virus, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).
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